TABLE 2.
Results of H4 acetylation in A2780 biopsies and tumors during belinostat treatment in vivo (Experiment 3)
| A2780 |
H4 acetylation |
|||||||
|---|---|---|---|---|---|---|---|---|
| Belinostat, 100 mg/kg i.v. |
||||||||
| ID | Pretreatment biopsy | 1 hbiopsy | 2 hbiopsy | 3 hbiopsy | 3 htumor | 6 hbiopsy | 6 htumor | 24 htumor |
| Large tumors (1500–1800 mg) | ||||||||
| 235 | Weak | Strong | Weak | |||||
| 234 | Moderate | Strong | Moderate | |||||
| 226 | Weak | Strong | Weak | |||||
| 365 | Moderate | Strong | Moderate | |||||
| 232 | Weak | Strong | Moderate | |||||
| 233 | No | No | No | |||||
| 553 | – | Weak | Weak | |||||
| Small tumors (300–400 mg) | ||||||||
| 227 | Strong | Weak | ||||||
| 238 | Strong | Moderate | ||||||
| 237 | Strong | Strong | ||||||
| 231 | Strong | – | ||||||
| 225 | Moderate | Moderate | ||||||
| 236 | Strong | Moderate | ||||||
| 228 | Strong | Weak | ||||||
| 230 | Weak | Weak | ||||||
| 552 | No | |||||||
Strong H4 acetylation is observed in biopsies collected 1 and 2 h after treatment. In most samples, acetylation is decreased after 3 h to a level similar to that observed in the pretreatment biopsies. Only weak acetylation is observed 6 h after treatment. (–, missing).