Figure 5.

Effect of CaMKII inhibition on AP-evoked SR Ca²⁺ transients and SR Ca²⁺ waves during metabolic acidosis. (a, b) Representative 10 s recordings of AP-evoked SR Ca²⁺ transients (0.5 Hz) in control conditions (left panels) and after 5 min of metabolic acidification (right panels) in the absence (a) and presence of KN-93 (b). During acidification a Ca²⁺ wave was observed in the absence of KN-93. (c) Effect of KN-93 on amplitudes of AP-evoked SR Ca²⁺ transients during acidosis relative to those observed under control conditions and (d) the number of Ca²⁺ waves observed during 2 min sampling periods during control conditions and during acidosis. Average data are shown as mean ± SEM.