Table 1. Experimental Animal Models of Valvular Heart Disease.
List of Experimental Models of Aortic Valve Disease.
| Author | Year | Model | Diet | Medical Therapy | Experimental Results |
|---|---|---|---|---|---|
| Rabbit | |||||
| Sarphie(38) | 1985 | New Zealand White Rabbit | Cholesterol | None | Endothelial structral changes along aortic surface of the aortic valve |
| Sarphie(37) | 1985 | New Zealand White Rabbit | Cholesterol | None | Anioic Surface Properties of the Endothelium |
| Sarphie(36) | 1986 | New Zealand White Rabbit | Cholesterol | None | Cytochemical Surface Properties |
| Sarphie(35) | 1987 | New Zealand White Rabbit | Cholesterol | None | Interactions of IgG and beta VLDL |
| Rajamannan(30) | 2001 | New Zealand White Rabbit | Cholesterol | None | Apoptosis |
| Rajamannan(10) | 2002 | New Zealand White Rabbit | Cholesterol | Atorvastatin | Cell Proliferation, Extracellular Matrix production, Foam Cell Formation, Cbfal expression, Statin Inhibits Cell Proliferation and Matrix |
| Rajamannan(21) | 2005 | New Zealand White Rabbit | Cholesterol | Atorvastatin | eNOS expression and Regulation in the Aortic Valve, Calcification |
| Rajamannan(40) | 2005 | Watanabe Rabbit/LDLR−/− | Cholesterol | Atorvastatin | Lrp5/Wnt/Cbfa1 regulation in severely calcified aortic valves and regulation of cell proliferation in myofibroblast cell culture |
| Drolet{31) | 2003 | New Zealand White Rabbit | Cholesterol and Vitamin D | None | Hemodynamic Evidence of Early Stenosis |
| Cimini(39) | 2005 | New Zealand White Rabbit | Cholesterol | None | Early Aortic Valve Sclerosis and Atherosclerosis |
| Arishiro(43) | 2007 | Japanese Rabbit | Cholesterol | Olmesartan | ARB1 inhibits endothelial disurption and atherosclerosis |
| Mouse Species | |||||
| Shao(61) | 2005 | LDLR−/− | Cholesterol | None | Valvular Fibrosis via Wnt-Msx2 Regulation |
| Drolet(34) | 2006 | LDLR−/− | Cholesterol | None | Hemodynmic Evidence of Early Stenosis and Metabolic Syndorme |
| Weiss (32) | 2006 | LDLR−/−Apob100/100 | Cholesterol | None | Hemodynamic Evidence of Severe Stenosis, Mineralization and Abnormal Oxidative stress |
| Aikawa(33) | 2007 | ApoE−/− | Cholesterol | None | Multiomodality imaging in Atherosclerotic Aortic Valves- Measuring Osteogenic Activites |
| Tanaka (45) | 2007 | ApoE−/− | Cholesterol | None | Mechanistic study for Aortic valve Disease |