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. Author manuscript; available in PMC: 2009 Nov 6.
Published in final edited form as: Arthritis Rheum. 2008 Nov;58(11):3520–3529. doi: 10.1002/art.23999

Figure 1. MAP kinase activities in DNp38 transgenic mice.

Figure 1

a) Reduction of phosphorylated p38 MAPK activity in cartilage of DNp38 transgenic mice (+/−) in comparison to that of WT mice (−/−) at 53 weeks of age. Western blot analysis of mouse cartilage extract was performed with an antibody against phosphorylated p38 MAPK (p-p38) and an antibody against p38 protein (p38), respectively. Equal amount of protein was loaded in each lane. Densitometry quantification of the protein bands was shown (error bars indicated standard deviation).

b) Reduction of phosphorylated p38 MAPK activity in growth plate cartilage of DNp38 transgenic mice (+/−) in comparison to that of WT mice (−/−) at birth. Immunohistochemical analysis of mouse growth plate cartilage was performed using an antibody against phosphorylated p38 MAPK (p-p38) and an antibody against p38 protein (p38), respectively.