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. 2009 Nov 6;106(47):20057–20062. doi: 10.1073/pnas.0905529106

Fig. 2.

Fig. 2.

Impaired mitochondrial enzyme activities and decreased ATP levels in cortical brain cells from tripleAD mice. (A) Complex I activity (DBQ/HAR ratio) was decreased in 8-month-old pR5 mitochondria. At 12 months, all 3 transgenic mouse models presented a decrease in complex I activity. (B) Citrate synthase (CS) activity was increased in 8-month-old APP/PS2 and tripleAD mice. At 12 months, the increase persisted only in tripleAD mice. (C) Complex IV activity (CIV/CS ratio) was decreased in APP/PS2 and tripleAD mitochondria at 8 months of age. The decrease became more pronounced at the age of 12 months. (D) ATP levels were reduced in 12-month-old APP/PS2 and triple mice. (A–D) One-way ANOVA post hoc Tukey's. *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. wild type; +, P < 0.05 vs. pR5 (n = 7–12 animals/group).