Table 1.
Characteristics and comparison of COPD and healthy subject groups
| COPD (n = 74) | Healthy (n = 35) | p value | |
| MFI 20 General Fatigue | 13 (5) | 8 (4) | p < 0.001 |
| MFI 20 Physical Fatigue | 16 (5.25) | 7 (5) | p < 0.001 |
| MFI 20 Reduced Activity | 13.5 (6) | 6 (5) | p < 0.001 |
| MFI 20 Reduced Motivation | 10 (6) | 6 (4) | p < 0.001 |
| MFI 20 Mental Fatigue | 8 (7) | 6 (4) | p = 0.008 |
| % FEV1 | 46.5(20.0) | 96.5(13.2) | p < 0.001 |
| FEV1/FVC ratio | 0.44 (0.13) | 0.78(0.1) | p < 0.001 |
| Age (yrs) | 69.9 (8.4) | 67.11 (8.8) | NS |
| BMI (kg/m2) | 26.2 (5.4) | 25.2 (3.4) | NS |
| FFMI (kg/m2) | 18.2 (2.6) | 17.9 (2.2) | NS |
| Depression (HADS) | 6 (5) | 1 (3) | p < 0.001 |
| Anxiety (HADS) | 7 (6) | 3 (4) | p < 0.001 |
| Peak Tq (% BW) | 38.6 (12.0)* | 51.6 (14.5) | p < 0.001 |
| ISWT (m) | 343.3 (183.9) * | - | - |
| Post walk SpO2 (%) | 90.0(5.9)* | - | - |
| Borg exertion (RPE) | 13(2.0)* | - | - |
| IL 6 (pg/mL) (n = 57) | 5.4(5.9) * | - | - |
| MRC dyspnoea score | 3 (2) | - | - |
| SGRQ | 56.0 (27.4) | - | - |
Data presented as median (IQR) for MFI 20-Multidimensional Fatigue Inventory, HADS - Hospital Anxiety and Depression scale, SGRQ - Saint George's Respiratory Questionnaire, total score, Borg exertion, MRC score or mean (SD) for % FEV1 - % predicted forced expiratory volume in one second, FEV1/FVC - Forced Expiratory Volume in one second/Forced Vital Capacity, BMI - Body Mass Index; FFMI - Fat Free Mass Index; Peak Tq (% BW) - quadriceps peak torque (% Body Weight), ISWT - Incremental Shuttle walk test, SpO2 - Percutaneous arterial oxygen saturation. *not measured in home-assessed patients (n = 59).