Table 2.

Distribution of metastatic tumor determined on histology and imaging

	Group 1					Group 2	Group 3
%	Day 1 (n = 4)	Day 3 (n = 4)	Week 1 (n = 5)	Week 2 (n = 3)	Week 3 (n = 1)	(n = 8)	(n = 5)
Braina	0	0	80	100	100	87.5	80
Spinal Corda	0	0	80	100	100	87.5	80
Lunga	0	0	0	20	0	50	60
Livera	0	0	20	33.3	100	0	0
Kidneya	0	0	60	100	100	87.5	60
Lymph Nodea	0	0	100	100	100	100	100
Heart	0	0	0	0	0	0	0
Boneb	100	100	100	100	100	100	80

Note. a. Tumor cells within the vasculature or tissue on day 1 and 3 were not counted.

b. Positive tumor cells detected by immunohistochemical staining of bone marrow sample were considered as positive lesion on group 1 rats. Group 2 rats underwent histological examination of long bone and spine for bone tumor determination. In group 3 rats, bone tumor lesions were determined on MRI and BLI.