Table 1.
Neutralizing activity of VH7183/JH2-positive VSV-specific IgG monoclonal antibodies
| Clone | Ig subclass | Neutralizing activity, titer⋅μg−1⋅ml−1* |
|---|---|---|
| Primary day 4 | ||
| 41.6 | IgG2a/κ | 3 |
| Secondary day 12 | ||
| VI26 | IgG2a/κ | 100 |
| VI30 | IgG2a/κ | 100 |
| VI22 | IgG2a/κ | 820 |
| VI20 | IgG3/κ | 1,200 |
| VI24 | IgG2a/κ | 800 |
| Hyperimmune day 150 | ||
| VI53 | IgG2a/κ | 760 |
| VI51 | IgG3/κ | 850 |
| VI55 | IgG2b/λ | 330 |
| VI52 | IgG2a/κ | 850 |
| VI43 | IgG2a/κ | 680 |
*
Neutralizing activity is expressed as the standardized neutralizing titer of monoclonal antibodies with a starting concentration of 1 μg/ml.