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Western blot of IGF-II, Bcl-2 and Bcl-XL following IGF-II siRNA treatment in MCF-7 cells. (A) Western blot of proIGF-II secretion 9 h after RSV and IGF-II siRNA treatment. The 17 kDa band represents proIGF-II and is the only IGF-II form secreted by MCF-7 cells. (B) Shows IGF-II siRNA and RSV effects on Bcl-2 and Bcl-XL protein levels in the presence or absence of recombinant IGF-II (mature or precursor forms, 100 ng/ml).
