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. Author manuscript; available in PMC: 2009 Nov 7.
Published in final edited form as: Growth Factors. 2008 Apr;26(2):92–103. doi: 10.1080/08977190802057258

Figure 5.

Figure 5

Western blots of (A) phospho-IRS-1 (Tyr1179 and Ser641), (B) phospho-Akt (T308 and T473), (C) phospho-ERK 1/2, from MCF-7 cells treated with RSV (10−4 M) and/or IGF-II (mature or precursor forms, 100 ng/ml). Total IRS-1, Akt and ERK are shown for each treatment time, and (D) shows Western blots of CREB (cytosolic fraction), phospho-CREB (nuclear fraction) following 20 min RSV and IGF-II treatments. β-actin and recombinant IGF-I were used as loading controls for the cytosolic and nuclear fractions, respectively.