Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
VHR containing a CBM is not able to dephosphorylate amylopectin. (A) Amino acids 1–162 of laforin containing laforin’s CBM were fused in frame to amino acids 35–185 of VHR followed by a 6His tag. The alignment of laforin with that of VHR is shown at the fusion point. (B) Phosphatase assays utilizing laforin and CBM-VHR were performed using pNPP as a substrate (left graph) or amylopectin as a substrate (right graph). Error bars represent the SEM.
