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. Author manuscript; available in PMC: 2009 Nov 7.
Published in final edited form as: Lancet. 2008 May 24;371(9626):1800–1809. doi: 10.1016/S0140-6736(08)60768-0

Figure 2. Diabetic dyslipidemia and the vessel wall.

Figure 2

Insulin resistance and relative insulin deficiency in T2DM leads to abnormal lipoprotein particle number, size and composition. These lipoprotein changes impact gene expression and lipid flux in macrophages, endothelial cells, and arterial smooth cells to favor increased lipoprotein retention, sterol content, and inflammatory response in the vessel wall. These changes in the vessel wall favor growth of the atherosclerotic plaque and may predispose to instability and plaque rupture.