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Proposed human metabolic pathways of letrozole and the specific cytochrome P450 (CYP) isoforms involved. There is no full publication describing in detail the precise metabolic pathways and CYPs involved in letrozole metabolism. Thus, the schematic presentation is based on information provided in the letrozole label [17] and our own data published in abstract form (16). *Represents the ketone analog of 4,4′-methanol-bisbenzonitrile
