Table 2.
Urinary excretion of toxic metals in Phase 1, at baseline, after 1st dose, and after 9th dose, in mcg/g creatinine.
| Element | Baseline | 1st Dose | 9th Dose | 1st dose vs. baseline | 9th dose vs. baseline |
| Pb | 1.3 +/- 2.3 | 10. +/- 19. | 9.2 +/- 7.8 | 713%*** | 638%*** |
| Sn | 2.3 +/- 3.4 | 8.0 +/- 13 | 9.7 +/- 24 | 241%*** | 314%* |
| Bi | 0.18 +/- 0.45 | 0.47 +/- 1.4 | 0.41 +/- 1.0 | 161%+ | 128%* |
| U | 0.015 +/- .04 | 0.036 +/- .09 | 0.031 +/- .1 | 104% | 111% |
| Hg | 0.86 +/- .92 | 1.5 +/- 1.4 | 0.97 +/- 0.88 | 70%** | 13% |
| Tl | 0.15 +/- 0.12 | 0.25 +/- 0.18 | 0.21 +/- 0.19 | 67%*** | 42%** |
| Sb | 0.10 +/- 0.10 | 0.15 +/- 0.19 | 0.14 +/- 0.20 | 49%* | 42%+ |
| W | 0.39 +/- 0.29 | 0.59 +/- 0.63 | 0.46 +/- 0.50 | 51%** | 18%* |
| Al | 16 +/- 21 | 18 +/- 23 | 19 +/- 33 | 11% | 21% |
| Ni | 6.7 +/- 5.1 | 5.5 +/- 3.6 | 7.6 +/- 4.3 | -18%* | 12% |
| Cd | 0.38 +/- 0.24 | 0.40 +/- 0.24 | 0.33 +/- 0.23 | 5% | -14% |
| As | 32 +/- 20 | 32 +/- 18 | 25 +/- 18 | 0% | -19%* |
| creatinine | 94 +/- 52 | 62 +/- 39 | 80 +/- 43 | -34%*** | -15%* |
+ P < 0.1
*P < 0.05
** P < 0.01
*** P < 0.001
Creatinine values have units of mg/dl. N = 63. The metals are listed in approximate order of effect of DMSA on excretion. Significant results are highlighted in bold font.