Table 4.
Glutathionylation Targets in Neurodegenerative Diseases
| Protein | Challenge to induce glutathionylation | Effect on activity | Evidence in disease | Reference |
|---|---|---|---|---|
| Actin | Increased iron found in fibroblasts of patients | Inhibitory | Freidriech's ataxia | 230 |
| GAPDH | Isolated fibroblasts from HD and AD patients | Inhibitory | Alzheimer's disease, Huntington's disease | 195 |
| Complex I | Increased GSSG | Inhibitory | Parkinson's disease | 23 |
| IDPm | MPTP in mice | Inhibitory | Parkinson's disease | 152 |
| E1 Ubiquitin Enzyme | BSO in PC12 Cells | Inhibitory | Parkinson's disease | 133 |
| α-Ketoglutarate dehydrogenase | H2O2 in HEK293 cells | Inhibitory | Alzheimer's disease | 275 |
The table provides a listing of various proteins that have been implicated as targets of glutathionylation and corresponding inhibition of protein function within the context of oxidative stress associated with neurodegenerative diseases.