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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Arch Gen Psychiatry. 2009 Apr;66(4):431–441. doi: 10.1001/archgenpsychiatry.2009.2

Figure 5.

Figure 5

Significant main effect of drug on cingulate circuitry based on paired t-tests. Seven resting-state functional connectivity pathways were statistically enhanced by nicotine administration (red) when compared to placebo. See Table 3 for the coordinates and the extents of each significant cluster. There was never a statistically significant reduction in functional connectivity by nicotine. Ovals indicate the seed ROIs. Arrows infer the relationship between the seed ROI and the areas that were affected by nicotine and do not imply directionality of the functional connectivity path. These figures represent the nicotine-placebo differences in Figure 2 that were statistically significant.