TABLE 3. Tissue distribution of activity of 18F-1.
Mean percent injected dose per gram ± SD (n = 5) |
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Tissue/organ | 1 h | 1 h (blocked)a | 2 h | 2 h (blocked)a |
Blood | 0.07 ± 0.01 | 0.05 ± 0.02 | 0.04 ± 0.01 | 0.04 ± 0.01 |
Lung | 0.06 ± 0.01 | 0.06 ± 0.01 | 0.04 ± 0.02 | 0.04 ± 0.01 |
Liver | 11.52 ± 3.80 | 8.36 ± 2.21 | 6.28 ± 1.89 | 5.51 ± 1.91 |
Spleen | 0.13 ± 0.03 | 0.13 ± 0.03 | 0.07 ± 0.03 | 0.10 ± 0.04 |
Kidney | 0.17 ± 0.05 | 0.14 ± 0.03 | 0.09 ± 0.02 | 0.08 ± 0.02 |
Muscle | 0.04 ± 0.01 | 0.03 ± 0.01 | 0.02 ± 0.00 | 0.01 ± 0.00 |
White Fat | 0.05 ± 0.02 | 0.02 ± 0.01 | 0.01 ± 0.00 | 0.01 ± 0.00 |
Brown Fat | 0.13 ± 0.01 | 0.07 ± 0.01 | 0.12 ± 0.03 | 0.08 ± 0.01 |
Heart | 0.07 ± 0.01 | 0.06 ± 0.02 | 0.04 ± 0.01 | 0.04 ± 0.01 |
Bone | 0.04 ± 0.01 | 0.04 ± 0.01 | 0.03 ± 0.00 | 0.03 ± 0.01 |
Animals were cotreated with 15 μg of Farglitazar to block PPARγ mediated uptake.