Table 2. Cocaine Dose-Response Study.

Data are expressed as mean (±SD) of ³H-DAMGO binding. Animals received a single injection of saline (1 ml/kg i.p.) or cocaine (2.5, 10 or 20 mg/kg i.p.) and were euthanized ten minutes later. ³H-DAMGO binding was determined and expressed as a % of that in saline controls. One-way ANOVA showed no significant differences in ³H-DAMGO binding in any region listed. (N=4/group)

	Saline		2.5 mg/kg Cocaine		10 mg/kg Cocaine		20 mg/kg Cocaine
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
CP	99.9	18.8	96.2	16.5	95.6	21.2	115.1	19.7
OT	100.1	16.9	98.6	33.9	85	10.9	91.2	10.9
Cingulate Cortex	100	9.1	97.6	8.8	90.3	9.9	97.3	4.8
Motor Cortex 2	99.9	9.9	97.3	7.9	84.9	13.4	92.2	7.4
Rostral VTA	100	9.1	102.9	14.6	89.2	14.6	103.8	23.8
Caudal VTA	100	6.2	105.7	17.1	102.7	11.9	107.2	6.7