Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pro-epileptic effect of histamine and pilocarpine mediated by enhancement of BBB permeability. (A) Arterial co-perfusion of 100 μM histamine and 800 μM pilocarpine in the isolated guinea-pig brain induces a sustained ictal epileptiform discharge in area CA1 of the hippocampus. (B) The BBB-impermeable atropine methyl bromide (5 μM) reduces fast activity induced by 800 μM pilocarpine, when co-perfused for 10 min with the BBB-opener histamine (100 μM).
