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. Author manuscript; available in PMC: 2009 Nov 9.
Published in final edited form as: Neuroscience. 2007 Nov 12;151(1):303–312. doi: 10.1016/j.neuroscience.2007.10.037

Fig. 6.

Fig. 6

Pilocarpine/histamine-induced seizure-like activity is not determined by potassium enhancement. (A) Perfusion of 800 μM pilocarpine is followed by an increase of [K+]o that correlates with the development of fast oscillatory activity in the field potential (FP) of CA1. In the bottom panel, details of the fast activity at time points a, b and c are illustrated. The duration of the pilocarpine perfusion is shown by the gray bar. (B) Comparable increase of [K+]o is observed at the onset pilocarpine 800 μM and histamine 100 μM co-perfusion (arrowhead); a subsequent large increase in [K+]o is associated to the onset of ictal discharges (arrow). The duration of the histamine–pilocarpine co-perfusion is shown by the gray bar.