Table 3.
Sensitivity, specificity, positive and negative predictive values of CareStart™ Malaria 2 line pLDH (Pan) results compared to microscopy results
| Sensitivity | Specificity | Positive Predictive Value | Negative Predictive Value | |
|
PF/other1 (PF gametocytaemia considered negative for PF) |
89.1 [85.5-91.8] |
97.6 [96.5-98.4] |
93.8 [90.8-95.9] |
95.2 [94.2-96.8] |
|
PF/other2 (PF gametocytaemia considered positive for PF) |
85.1 [81.3-88.2] |
96.1 [94.7-97.2] |
90.6 [87.3-93.2] |
93.6 [91.9-95.0] |
|
PF mono-infection1 (PF gametocytaemia considered negative for PF) |
95.6 [87.7-98.5] |
- | - | - |
|
PF mono-infection2 (PF gametocytaemia considered positive for PF) |
86.7 [79.9-91.4] |
- | - | - |
|
PV mono-infection1 (PV gametocytaemia considered negative for PV) |
91.0 [86.5-94.1] |
- | - | - |
|
PV mono-infection2 (PV gametocytaemia considered positive for PV) |
88.4 [83.7-91.9] |
- | - | - |
Note
1329 CareStart™ Malaria 2 line pLDH (Pan) tests performed; 13 (1%) were invalid, results were missing for 1 (0.1%) test., thus results of 1315 tests were evaluated.
Results expressed as % with 95% confidence intervals in brackets
Specificity not calculated for monoinfections since false positives for species individually cannot be estimated.
1 Solitary gametocytaemia considered as a negative result for that species
2Solitary gametocytaemia considered as a positive result for that species