Table 3.
Selected targets
| CI | YPTB Locus | Definition | 50-90 Cluster ID | Total non-pathogens | Total pathogens | Pathogen strains |
| 0.01 | 2410 | Magnesium transport ATPase mgtB | 1035 | 3 | 8 | Bme, Bma, Bp |
| 0.03 | 2913 | Deoxyribopyrimidine photolyase phrB | 2801 | 0 | 6 | Vc |
| 0.06 | 2705 | Putative manganese transport protein mntH | 1611 | 3 | 8 | Ba, Bma, Bp |
| 0.12 | 3827 | Outer membrane biogenesis protein | 2798 | 0 | 5 | - |
| 0.13 | 0181 | Putative protohaeme IX biogenesis protein hemY | 3642 | 0 | 5 | - |
| 0.16 | 0756 | Superoxide dismutase C sodC | 1306 | 0 | 9 | Bme, Cb, Ft, Vc |
| 0.39 | 1340 | Lysine specific permease cadR | 563 | 2 | 9 | Ba, Bma, Bp, Ft |
| 0.42 | 0242 | Glycerophosphoryl diester phosphodiesterase glpQ | 2411 | 0 | 7 | Bma, Bp |
| 0.45 | 2699 | Hypothetical protein | 3924 | 0 | 7 | Bma, Bp |
| 0.76 | 1424 | Hypothetical protein | 1031 | 3 | 9 | Bma, Bp, Ft, Vc |
| 0.87 | 3166 | Thiol:disulphide interchange protein dscB | 3283 | 0 | 5 | - |
| 2.38 | 0188 | Frataxin-like protein cyaY | 2139 | 2 | 6 | Vc |
| 3.15 | 3505 | Stringent starvation protein sspB | 1207 | 3 | 7 | Cb, Vc |
| ND | 1167 | Phosphate starvation protein | 3911 | 0 | 6 | - |
| ND | 1251 | Ecotin | 3380 | 0 | 6 | - |
| ND | 2026 | MviN-like protein | 1296 | 3 | 9 | Bma, Bp, Cb |
| ND | 2995 | Putative surface antigen | 2296 | 2 | 7 | Vc |
Virulence-associated genes identified by computational methods and selected for experimental screening. These targets have been ranked by their competitive index (CI) value in Y. pseudotuberculosis. The CI value shown is the mean of the CI calculated from 3 spleens individually plated in triplicate. The top six candidates are deemed virulence-related by our experimental criteria. Hits to pathogens include all five members of the Enterobacteriaceae (Ec, Se, Sf, St, Yp) plus the additional strains listed using abbreviations from Table 1.