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Cartoon demonstrating the signaling pathways for the up-regulation of CXCR4 expression on fibrocytes related to the role of hypoxia and activation of the PI3K/AKT/mTOR pathway that culminates in promoting trafficking of CXCR4+ fibrocytes to the lung in response to CXCL12. VHL, Von Hippel-Lindau; GF, growth factor.
