Clinical stage 1: asymptomatic
Clinical stage 2: moderate disease
■ Unexplained moderate weight loss of less than 10% of baseline weight ■ Recurrent upper respiratory infections (sinusitis, otitis media, tonsillitis, pharyngitis) ■ Mono-dermatomal VZV (shingles) ■ Recurrent oral ulceration ■ Papular pruritic eruptions/dermatitis ■ Seborrheic dermatitis ■ Fungal nail infections
Clinical stage 3: advanced disease
■ Unexplained weight loss above 10% of baseline ■ Unexplained chronic diarrhea for more than 1 month ■ Unexplained persistent fever (>37.5°C, intermittent or constant) for more than 1 month ■ Persistent oral candidiasis ■ Oral hairy leukoplakia ■ Pulmonary TB ■ Severe bacterial infections (e.g., pneumonia, meningitis, PID*, bone/joint infection, bacteremia) ■ Multidermatomal, recurrent mono-dermatomal or ophthalmic VZV* ■ Necrotizing ulcerative gingivitis, peridontitis or stomatitis ■ Unexplained anemia (<8.0 gr/dl), neutropenia (<500/μl) and/or thrombocytopenia (<50,000/μl)
Clinical stage 4: severe disease
■ HIV-1 wasting syndrome ■ Pneumocystis jiroveci (formerly carinii) pneumonia ■ Recurrent severe bacterial pneumonia ■ Chronic HSV infection (orolabial, genital or rectal for more than 1 month or visceral at any site) ■ Esophageal candidiasis (or candidiasis of trachea, bronchi or lungs) ■ Extrapulmonary TB ■ Kaposi's sarcoma ■ Cytomegalovirus retinitis or infection of other organs ■ CNS toxoplasmosis ■ HIV-1 encephalopathy (AIDS dementia complex) ■ Extrapulmonary cryptococcosis, including meningitis ■ Disseminated non-TB mycobacterial infection ■ Progressive multifocal leukoencephalopathy ■ Chronic diarrhea due to cryptosporidiosis and/or isosporiasis ■ Disseminated mycosis ■ Recurrent septicemia ■ Lymphoma (cerebral or non-Hodgkin's) ■ Invasive cervical carcinoma ■ Atypical disseminated leishmaniasis ■ Symptomatic HIV-associated nephropathy and cardiomyopathy
|
