Table 3.
Univariate models* of candidate determinants of Medical Outcomes Study 36-Item Short Form (MOS SF-36) Physical Component Summary (PCS), MOS SF-36 Mental Component Summary (MCS), and St. George’s Respiratory Questionnaire total score (SGRQ-TS).
| Variable | MOS SF-36 PCS Score† |
MOS SF-36 MCS Score† |
SGRQ-TS‡ |
|||
|---|---|---|---|---|---|---|
| Unadjusted Coefficient (95% CI) |
p-Value | Unadjusted Coefficient (95% CI) |
p-Value | Unadjusted Coefficient (95% CI) |
p-Value | |
| Age | 0.17 | <0.001 | 0.13 | 0.002 | −0.45 | <0.001 |
| (0.12 to 0.23) | (0.05 to 0.21) | (−0.55 to −0.35) | ||||
| Current Oral Corticosteroid Use | −2.0 | <0.001 | −1.4 | 0.009 | 5.2 | <0.001 |
| (ref = no use) | (−2.7 to −1.2) | (−2.5 to −0.36) | (3.8 to 6.5) | |||
| Alcohol Use | 2.1 | <0.001 | 1.8 | <0.001 | −4.0 | <0.001 |
| (ref = never use) | (1.3 to 2.8) | (0.74 to 2.8) | (−5.3 to −2.7) | |||
| Disabled | −3.00 | <0.001 | −1.8 | 0.001 | 6.8 | <0.001 |
| (ref = nondisabled) | (−3.75 to −2.25) | (−2.9 to −0.74) | (5.4 to 8.1) | |||
| Daytime Sleepiness | –1.1 | <0.001 | −3.3 | <0.001 | 4.0 | <0.001 |
| (ref = never sleepy during day) | (−1.8 to −0.40) | (−4.3 to −2.3) | (2.7 to 5.2) | |||
| Antidepressant Use | –1.0 | 0.04 | −4.6 | <0.001 | 4.8 | <0.001 |
| (ref = no use) | (−1.9 to −0.06) | (−6.0 to −3.3) | (3.2 to 6.5) | |||
| Oxygen Use | −1.6 | <0.001 | –1.3 | 0.04 | 3.2 | <0.001 |
| (ref = no use) | (−2.4 to −0.78) | (−2.4 to −0.072) | (1.8 to 4.7) | |||
| Beck Total Score | −0.22 | <0.001 | −0.97 | <0.001 | 1.01 | <0.001 |
| (−0.28 to −0.17) | (−1.04 to −0.90) | (0.92 to 1.1) | ||||
| BMI (ref = BMI 18–25, n = 836) | ||||||
| BMI <18 | −1.8 | 0.06 | −2.3 | 0.09 | 4.2 | 0.02 |
| (Underweight, n = 61) | (−3.8 to 0.05) | (−5.1 to 0.39) | (0.80 to 7.55) | |||
| BMI 25–30 | 0.02 | NS | 1.1 | 0.05 | −0.14 | NS |
| (Overweight, n = 547) | (−0.77 to 0.81) | (−0.011 to 2.2) | (−1.5 to 1.3) | |||
| BMI >30 | −1.7 | 0.004 | −0.91 | NS | 2.8 | 0.01 |
| (Obese, n = 177) | (−2.9 to −0.55) | (−2.6 to 0.79) | (0.67 to 4.9) | |||
| Sex | −0.24 | NS | −1.4 | 0.008 | 0.46 | NS |
| (ref = male) | (−0.96 to 0.49) | (−2.5 to −0.37) | (−0.83 to 1.8) | |||
| Education | 0.51 | NS | 4.6 | <0.001 | −4.7 | <0.001 |
| (ref = not high school graduate) | (−0.39 to 1.4) | (3.3 to 5.8) | (−6.3 to −3.2) | |||
| Race | −0.11 | NS | −1.3 | NS | −0.67 | NS |
| (ref = white) | (−1.61 to 1.39) | (−3.4 to 0.84) | (−3.3 to 2.0) | |||
| Marital Status | −0.16 | NS | −1.2 | 0.03 | 1.2 | 0.07 |
| (ref = married) | (−0.90 to 0.58) | (−2.2 to −0.09) | (−0.086 to 2.6) | |||
| Prior Rehabilitation | 0.17 | NS | 0.19 | NS | −0.36 | NS |
| (ref = no rehabilitation) | (−0.57 to 0.91) | (−0.87 to 1.24) | (−1.7 to 0.95) | |||
| Cigarette Smoking | −0.001 | NS | −0.021 | 0.02 | 0.028 | 0.008 |
| (−0.013 to 0.011) | (−0.037 to −0.004) | (0.007 to 0.049) | ||||
| Antianxiety Medication Use | −0.75 | NS | −3.3 | <0.001 | 4.08 | <0.001 |
| (ref = no use) | (−1.86 to 0.36) | (−4.9 to −1.7) | (2.12 to 6.04) | |||
| LVEF | −0.80 | NS | 3.2 | 0.03 | −0.33 | NS |
| (ref = 45%) | (−2.77 to 1.17) | (0.38 to 6.02) | (−3.8 to 3.2) | |||
| PaCO2 | −0.02 | NS | −0.099 | 0.03 | 0.076 | NS |
| (−0.08 to 0.04) | (−0.19 to −0.008) | (−0.036 to 0.19) | ||||
| CT Emphysema Score | −0.005 | NS | 0.039 | NS | 0.12 | NS |
| (−0.095 to 0.085) | (−0.09 to 0.17) | (−0.04 to 0.28) | ||||
*
Example of univariate model: MOS SF-36 PCS Score = (0.17) × (Age).
†
Higher score indicates better health status.
‡
Lower score indicates better health status.
Beck = Beck Depression Inventory, BMI = body mass index, CI = confidence interval, CT = computed tomography, LVEF = left ventricular ejection fraction, NS = nonsignificant, PaCO2 = partial pressure of arterial carbon dioxide, ref = reference.