Table 4.
Significant determinants of Medical Outcomes Study 36-Item Short Form (MOS SF-36) Physical Component Summary (PCS) score (model R2 = 0.24 ), MOS SF-36 Mental Component Summary (MCS) score (model R2 = 0.35), and St. George’s Respiratory Questionnaire total score (SGRQ-TS) (model R2 = 0.55) in multivariate models* (n = 1,621).
| Determinant | MOS SF-36 PCS Score† |
MOS SF-36 MCS Score† |
SGRQ-TS‡ |
|||
|---|---|---|---|---|---|---|
| Adjusted Coefficient (95% CI) |
p-Value | Adjusted Coefficient (95% CI) |
p-Value | Adjusted Coefficient (95% CI) |
p-Value | |
| 6MWT Distance | 0.0042 | 0.02 | 0.0025 | 0.29 | −0.006 | 0.02 |
| (0.0005 to 0.0080) | (−0.0022 to 0.0072) | (−0.011 to −0.001) | ||||
| UCSD SOBQ Total Score | −0.16 | <0.001 | −0.07 | <0.001 | 0.37 | <0.001 |
| (−0.18 to −0.14) | (−0.10 to −0.04) | (0.34 to 0.39) | ||||
| 6MWT Borg | −0.22 | 0.007 | — | — | 0.24 | 0.03 |
| (−0.38 to −0.06) | (0.024 to 0.46) | |||||
| Age | 0.08 | 0.006 | — | — | −0.19 | <0.001 |
| (0.02 to 0.13) | (−0.27 to −0.12) | |||||
| Beck Total Score | — | — | –0.82 | <0.001 | 0.48 | <0.001 |
| (−0.89 to −0.74) | (0.40 to 0.55) | |||||
| Antidepressant Use | — | — | −1.6 | 0.004 | ||
| (ref = no use) | (−2.7 to −0.50) | |||||
| DLCO, % predicted | −0.05 | 0.008 | — | — | 0.07 | 0.008 |
| (−0.08 to −0.01) | (0.02 to 0.11) | |||||
| Education | — | — | 2.3 | <0.001 | — | — |
| (ref = not high school graduate) | (1.2 to 3.3) | |||||
| Daytime Sleepiness | — | — | −1.3 | 0.002 | 1.5 | <0.001 |
| (ref = never sleepy during day) | (−2.2 to −0.49) | (0.65 to 2.4) | ||||
| Disabled | −1.1 | 0.002 | — | — | 1.8 | <0.001 |
| (ref = nondisabled) | (−1.9 to −0.41) | (0.77 to 2.8) | ||||
| Race | — | — | — | — | −2.6 | 0.005 |
| (ref = white) | (−4.4 to −0.79) | |||||
| Current Oral Corticosteroid Use | — | — | — | — | 2.2 | <0.001 |
| (ref = no use) | (1.3 to 3.1) | |||||
| Oxygen Use | — | — | — | — | −1.4 | 0.01 |
| (ref = no use) | (−2.5 to −0.34) | |||||
| Prior Rehabilitation | — | — | — | — | −1.2 | 0.008 |
| (ref = no rehabilitation) | (−2.1 to −0.33) | |||||
Note: Dash indicates variable not included in the model.
Example of multivariate model: MOS SF-36 PCS score = ((0.0042) × 6MWT distance + (−0.16) UCSD SOBQ total score + (−0.22) 6MWT Borg + (0.08) × age + (−0.05) × DLCO % predicted + (−1.1) × (disabled).
Higher score indicates better health status.
Lower score indicates better health status.
6MWT = 6-minute walk test; Beck = Beck Depression Inventory; Borg = Borg score for breathlessness; CI = confidence interval; DLCO = single-breath diffusing capacity of the lung for carbon monoxide; ref = reference; UCSD SOBQ = University of California, San Diego Shortness of Breath Questionnaire.