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. Author manuscript; available in PMC: 2010 May 5.
Published in final edited form as: Nature. 2009 Nov 5;462(7269):58–64. doi: 10.1038/nature08497

Figure 4. Proposed ERα-bound chromatin interaction and transcription regulation mechanism.

Figure 4

(a) Distal ERαBS interact with proximal sites, forming chromatin loops. Anchor genes (green and blue) are close to interaction anchors with concentrated active transcriptional machinery (red shading). Other genes far from interaction centers (grey) are less active. (b) Expression microarray data (oestrogen induction from 0 to 48h; red denotes activation; green denotes repression) for interaction anchor genes, loop genes, and genes near no-interaction ERαBS, with all other UCSC Genes29 (“All genes”) denoting background. (c) ChIA-PET interactions data at the FOS/JDP2/BATF loci. Transcription activities are shown by H3K4me3/RNAPII ChIP-Seq and RT-qPCR analysis (oestrogen induction from 0 to 24h).