Table 1.
Demographic and baseline characteristics (modified intent-to-treat population analysis set)
| TIW(n = 121) | QW(n = 124) | Q2W(n = 124) | Total(n = 369) | |
|---|---|---|---|---|
| Age (yr) | ||||
| Mean (SD) | 71.4 (12.88) | 68.8 (11.89) | 69.0 (13.04) | 69.7 (12.63) |
| Range | (33–94) | (37–95) | (30–101) | (30–101) |
| Sex [n (%)] | ||||
| Male | 45 (37.2) | 45 (36.3) | 39 (31.5) | 129 (35.0) |
| Female | 76 (62.8) | 79 (63.7) | 85 (68.5) | 240 (65.0) |
| Race [n (%)] | ||||
| White | 67 (55.4) | 64 (51.6) | 64 (51.6) | 195 (52.8) |
| Black | 42 (34.7) | 44 (35.5) | 41 (33.1) | 127 (34.4) |
| Asian | 0 | 1 (0.8) | 5 (4.0) | 6 (1.6) |
| Other | 12 (9.9) | 15 (12.1) | 14 (11.3) | 41 (11.1) |
| Baseline estimated glomerular filtration rate (ml/min) | ||||
| Mean (SD) | 30.68 (11.075) | 29.81 (11.175) | 29.49 (10.224) | 29.98 (10.812) |
| Range | (15.0–71.0) | (15.0–59.0) | (15.0–56.0) | (15.0–71.0) |
| Baseline hemoglobin (g/dl) | ||||
| Mean (SD) | 9.63 (0.861) | 9.71 (0.735) | 9.81 (0.748) | 9.72 (0.784) |
| Median | 9.70 | 9.80 | 10.00 | 9.90 |
| Range | (7.3–12.0) | (8.1–10.9) | (7.0–10.9) | (7.0–12.0) |
| Baseline ferritin level (pmol/L) | ||||
| Mean (SD) | 510.23 (376.686) | 573.81 (468.852) | 552.74 (439.828) | 545.98 (430.362) |
| Range | (33.0–1670) | (46.0–2187) | (26.0–2004) | (26.0–2187) |
| Primary cause of chronic kidney disease (CKD) [n (%)]a | ||||
| Total no. subjects with known CKDb | 123 (100) | 125 (100) | 123 (98) | 371 (99) |
| Diabetes | 68 (55) | 79 (63) | 72 (58) | 219 (59) |
| Hypertension | 88 (72) | 89 (71) | 80 (64) | 257 (69) |
| Glomerulonephritis | 3 (2) | 3 (2) | 5 (4) | 11 (3) |
| Renal vascular disease | 10 (8) | 2 (2) | 6 (5) | 18 (5) |
| Interstitial nephritis | 1 (1) | 1 (1) | 3 (2) | 5 (1) |
| Polycystic kidney disease | 0 | 1 (1) | 1 (1) | 2 (1) |
| Obstructive nephropathy | 4 (3) | 0 | 1 (1) | 5 (1) |
| Renal failure caused by metabolic disease | 1 (1) | 1 (1) | 3 (2) | 5 (1) |
| Toxic nephropathy | 2 (2) | 0 | 1 (1) | 3 (1) |
| Other | 1 (1) | 3 (2) | 5 (4) | 9 (2) |
Percentages calculated with the number of subjects in each group as denominator.
a
Data based on safety population.
b
Two subjects in the Q2W group had unknown underlying causes of CKD.
Q2W, every 2 wk; QW, once weekly; TIW, three times weekly.