Table 2.
Laboratory and vascular assessments according to groups
| Parameter | Control(n = 55) | CKD |
Pa | ||||
|---|---|---|---|---|---|---|---|
| Stage 1 (≥90; n = 57) | Stage 2 (60 to 89; n = 61) | Stage 3 (30 to 59; n = 60) | Stage 4 (15 to 29; n = 60) | Stage 5 (<15; HD; n = 57) | |||
| eGFR (ml/min per 1.73 m2; median [range]) | 118 (98 to 129) | 97 (88 to 108)b | 69 (60 to 93)b | 38 (17 to 58)b | 21 (15 to 37)b | 9 (2 to 14)b | <0.001 |
| Serum albumin (g/dl; median [range]) | 4.2 ± 0.4 | 4.1 ± 0.3 | 4.2 ± 0.3 | 4.2 ± 0.4 | 4.1 ± 0.3 | 4.0 ± 0.3 | 0.134 |
| SBP (mmHg; median [range]) | 131 (119 to 139) | 132 (115 to 157) | 133 (115 to 145) | 133 (110 to 142) | 131 (111 to 151) | 133 (113 to 141) | 0.803 |
| DBP (mmHg; median [range]) | 83.0 (76.0 to 89.0) | 82.0 (71.0 to 94.0) | 83.0 (73.0 to 90.0) | 84.5 (80.0 to 92.0) | 83.5 (71.0 to 93.0) | 83.0 (71.0 to 92.0) | 0.041 |
| Plasma insulin (μIU/ml; median [range]) | 6.8 (4.5 to 9.8) | 6.5 (5.0 to 9.7) | 6.7 (4.9 to 9.8) | 7.0 (4.9 to 13.0) | 6.7 (5.1 to 15.2) | 7.0 (5.5 to 13.5) | 0.107 |
| Plasma glucose (mg/dl; median [range]) | 85 (66 to 104) | 82 (70 to 108) | 88 (67 to 104) | 88 (68 to 105) | 90 (70 to 106) | 86 (68 to 109) | 0.057 |
| HOMA-IR (median [range]) | 1.3 (0.9 to 2.1) | 1.4 (1.0 to 2.4) | 1.4 (0.9 to 3.0) | 1.4 (1.0 to 3.1) | 1.4 (1.1 to 3.4) | 1.5 (1.1 to 3.0) | 0.070 |
| Total cholesterol (mg/dl; median [range]) | 192 (159 to 235) | 193 (160 to 231) | 194 (170 to 235) | 193 (171 to 237) | 192 (159 to 236) | 192 (149 to 235) | 0.092 |
| Triglycerides (mg/dl; median [range]) | 138 (115 to 167) | 137 (103 to 179) | 142 (106 to 159) | 138 (107 to 168) | 136 (124 to 162) | 137 (124 to 166) | 0.384 |
| LDL cholesterol (mg/dl; mean ± SD) | 122 ± 12 | 125 ± 16 | 130 ± 15 | 125 ± 16 | 126 ± 16 | 120 ± 20 | 0.031 |
| HDL cholesterol (mg/dl; median [range]) | 44 (27 to 53) | 46 (31 to 51) | 46 (26 to 54) | 43 (26 to 50) | 43 (28 to 63) | 43 (26 to 59) | 0.118 |
| hsCRP (mg/L; median [range]) | 2.0 (1.0 to 4.0) | 6.0 (3.2 to 10.0)b | 10.0 (5.0 to 15.0)b | 16.0 (6.5 to 22.0)b | 22.0 (8.0 to 28.0)b | 26.0 (11.0 to 37.0)b | <0.001 |
| NMD (%; median [range]) | 13.0 (11.9 to 13.9) | 13.0 (11.8 to 13.8) | 13.0 (12.4 to 13.8) | 12.9 (12.0 to 13.8) | 13.0 (11.6 to 13.8) | 12.0 (10.0 to 13.3)b | <0.001 |
| FMD (%; median [range]) | 9.0 (7.5 to 12.4) | 8.4 (7.2 to 9.7)b | 7.3 (6.7 to 8.3)b | 6.9 (6.2 to 8.2)b | 6.2 (5.2 to 8.2)b | 5.2 (4.0 to 7.2)b | <0.001 |
| sTWEAK (pg/ml; median [range]) | 445 (326 to 634) | 378 (146 to 678)b | 322 (145 to 479)b | 263 (142 to 381)b | 234 (139 to 357)b | 174 (114 to 313)b | <0.001 |
a
One-way ANOVA test.
b
Tukey-Kramer test, statistically (P < 0.05) compared with control group.