TABLE 2.

Pharmacokinetic constants for plasma HMMA after administration of 2 and 10 mg/kg MDMA to rats

Parameters were calculated from HMMA time-concentration profiles depicted in Fig. 4, with WinNonlin noncompartmental modeling. Data are the mean ± S.D. for n = 4–5 rats/group.

MDMA Treatment	HMMA Cmax	HMMA Tmax	HMMA AUC	HMMA t1/2
	ng/ml	h	h·ng/ml	h
2 mg/kg i.p.	186 ± 88	4.25 ± 0.87	926 ± 417	2.25 ± 0.23
2 mg/kg s.c.	236 ± 87	3.88 ± 0.75	1192 ± 251	2.66 ± 0.70
2 mg/kg p.o.	141 ± 59	3.86 ± 0.75	702 ± 257	2.57 ± 0.88
10 mg/kg i.p.	474 ± 268	5.50 ± 1.50	2478 ± 1433	2.73 ± 0.57
10 mg/kg s.c.	270 ± 106	6.20 ± 1.10	1373 ± 375	3.42 ± 2.23
10 mg/kg p.o.	309 ± 95	6.13 ± 1.75	1747 ± 467	3.26 ± 0.95