TABLE 4.

Pharmacokinetic constants for plasma HMA after administration of 2 and 10 mg/kg MDMA to rats

Parameters were calculated using WinNonlin version 5.2, and data are the mean ± S.D. for n = 4–5 rats/group. t_1/2 values could not be determined.

MDMA Treatment	HMA Cmax	HMA Tmax	HMA AUC
	ng/ml	h	h·ng/ml
2 mg/kg i.p.	13 ± 4	4.00 ± 0.87	67 ± 13
2 mg/kg s.c.	15 ± 2	4.00 ± 0.88	85 ± 12
2 mg/kg p.o.	N.D.	N.D.	N.D.
10 mg/kg i.p.	33 ± 12	6.60 ± 0.89	212 ± 67
10 mg/kg s.c.	23 ± 5	6.60 ± 1.01	146 ± 36
10 mg/kg p.o.	25 ± 8	6.00 ± 1.15	157 ± 57

N.D., not determined.