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SP600125 causes localization of β-catenin to cell-cell borders in a dose-dependent manner. Primary keratinocytes were treated with either vehicle (control) (A) or different concentrations of JNK inhibitor SP600125; 0.5 μM (B), 1 μM (C), 5 μM (D), or 10 μM (E). After 30 min, cells were fixed with 4% paraformaldehyde and immunostained for β-catenin. Nuclei were visualized with Hoechst 33258 (solid circles; view ×40). Scale bar = 20 μm.
