TABLE 3.
Apparent permeability coefficients (Papp; cm/s) of PS-NPs, deslorelin-PS-NPs, and transferrin-PS-NPs across the MTA, MTP, and ITP regions of excised bovine nasal tissue, based on a 4-h transport study
| Particle type | Region | m:s; 37°C | s:m; 37°C | m:s; 4°C | s:m; 4°C | Competition |
|---|---|---|---|---|---|---|
| PS-NP | MTA | 6.56E-07 ± 3.02E-08 | 6.11E-07 ± 1.87E-07 | |||
| MTP | 1.08E-06 ± 6.72E-08 | 1.19E-06 ± 2.53E-07 | ||||
| ITP | 1.49E-06 ± 2.23E-07 | 1.97E-06 ± 1.78E-07 | ||||
| Deslorelin-PS-NP | MTA | 2.32E-06 ± 3.73E-07 | 1.23E-06 ± 1.88E-07 | 0.00E+0.0 | 0.00E+0.0 | 1.82E-06 ± 1.01E-07 |
| MTP | 4.02E-06 ± 1.06E-07 | 3.30E-06 ± 1.94E-07 | 0.00E+0.0 | 0.00E+0.0 | 2.28E-06 ± 6.19E-07 | |
| ITP | 5.66E-06 ± 1.55E-08 | 4.70E-06 ± 1.76E-07 | 0.00E+0.0 | 0.00E+0.0 | 4.25E-06 ± 2.21E-07 | |
| Transferrin-PS-NP | MTA | 4.31E-06 ± 6.64E-08 | 7.19E-06 ± 1.35E-06 | 0.00E+0.0 | 0.00E+0.0 | 1.30E-06 ± 3.43E-07 |
| MTP | 5.83E-06 ± 1.17E-07 | 9.83E-06 ± 1.05E-06 | 0.00E+0.0 | 0.00E+0.0 | 1.77E-06 ± 5.76E-07 | |
| ITP | 7.58E-06 ± 1.11E-07 | 1.17E-05 ± 5.89E-07 | 0.00E+0.0 | 0.00E+0.0 | 5.29E-06 ± 2.74E-07 |
Permeability was measured at 37 and 4°C. Permeability was measured in both m:s and s:m directions. Deslorelin-PS-NPs and transferrin-PS-NPs did not exhibit any quantifiable transport at 4°C. PS-NP transport at lower temperatures was not performed. Data are expressed as means ± sd; n = 4.