TABLE 5.

Apparent permeability coefficient of plasmid-loaded PLGA-NPs, deslorelin-PLGA-NPs, and transferrin-PLGA-NPs across the ITP region of excised bovine tissue in the m:s direction, based on a 4-h transport study

Permeability	Plasmid alone	PLGA-NPs	Deslorelin-PLGA-NP	Transferrin-PLGA-NP
Particles (cm/s)	−	6.34E-06 ± 4.98E-07	8.76E-06 ± 1.02E-06*	1.02E-05 ± 4.04E-07*,†
Plasmid (cm/s)	2.00E-08 ± 2.01E-09	5.36E-07 ± 3.47E-08*	6.87E-07 ± 2.29E-08*,†	7.82E-07 ± 1.94E-08*,†,‡

Permeability of particles was assessed based on Nile red tracking. Data are expressed as means ± sd; n = 3. 

^*P < 0.05 vs. PLGA-NPs for particle permeability and plasmid-alone group for plasmid permeability; 

^†P < 0.05 vs. deslorelin-PLGA-NPs for particle permeability and PLGA-NPs for plasmid permeability; 

^‡P < 0.05 vs. deslorelin-PLGA-NPs for plasmid permeability.