TABLE 1.
Membrane protein complexes with TSPAN12 and CD81
| Name (protein ID) | TSPAN12 | CD81 |
|---|---|---|
| TSPAN12 (O95859)a | 5 | 0 |
| MMP14 (P50281)b | 10 | 0 |
| CD29 (P05556) (integrin β1)c | 6 | 0 |
| CD49c (P26006) (integrin α3)c | 3 | 0 |
| ADAM10 (O14672)c | 4 | 0 |
| CD44 (P16070)d | 9 | 0 |
| CD13 (P15144)eg | 3 | 1 |
| CD71 (P02786)e | 5 | 0 |
| ADAM17 (P78536)e | 3 | 0 |
| EGFR (P00533)e | 2 | 0 |
| EphA2 (P29317)f | 6 | 0 |
| CA08 (Q9bxs4)f | 3 | 0 |
| LRP 10 (Q7z4f1)f | 3 | 0 |
| CAV1 (Q03135) (caveolin 1)f | 2 | 0 |
| TR10B (O14763)f | 2 | 0 |
| CD81 (P60033)a | 0 | 1 |
| EWIF/FPRP (Q9P2B2)h | 0 | 12 |
Values represent number of distinct peptides. Complete peptide information is given in Supplemental Table S1.
a
As expected, TSPAN12 and CD81 yield TSPAN12 and CD81 peptides.
b
Association with MMP14 (MT1-MMP) has been seen elsewhere (21).
c
Association has been confirmed by coimmunoprecipitation.
d
TSPAN12-CD44 association is consistent with CD44 associating with other tetraspanins (47) and being a substrate for ADAM10 (48).
e
Coimmunoprecipitation experiments did not confirm interactions with TSPAN12.
f
These TSPAN12 interactions have not been tested further.
g
Interactions of CD13 with CD81 have been confirmed by coimmunoprecipitation.