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. Author manuscript; available in PMC: 2009 Nov 10.
Published in final edited form as: Curr Opin Microbiol. 2008 Feb 1;11(1):66–73. doi: 10.1016/j.mib.2007.12.001

Figure 3. TLR4 mediated inhibition of lipid raft mediated bacterial invasion of UPEC.

Figure 3

Lipid raft mediated bacterial uptake is initiated when FimH on UPEC ligates uroplakin 1a molecules found within lipid raft domains of the BEC plasma membranes. Once UPEC are internalized, they are encased in nondegradative compartments exhibiting properties of fusiform vesicles. The cAMP signaling pathway activated when TLR4 senses LPS abrogates this activity by acting on Rac-1, which is essential for actin remodeling.