Table 1.
Tandem Mass Spectrometry Parameters for Nicotine and Metabolites in Meconium
Period 1 | ||||||||
---|---|---|---|---|---|---|---|---|
Q1 Mass (amu) |
Q3 Mass (amu) |
Dwell Time (msec) |
DPa (volts) |
Entrance Potential (volts) |
CEPb (volts) |
Collision Energy (volts) |
CXPc (volts) |
|
OH-cotinined | 193.2 | 80.2* | 150 | 46 | 8.5 | 14.00 | 35 | 8 |
193.2 | 134.1 | 150 | 46 | 8.5 | 14.00 | 25 | 8 | |
OH-cotinine-D3 | 196.2 | 80.2* | 150 | 46 | 12.0 | 14.00 | 39 | 6 |
196.2 | 134.0 | 150 | 46 | 12.0 | 14.00 | 27 | 6 | |
Cotinine | 177.2 | 80.0* | 150 | 41 | 3.0 | 12.00 | 37 | 4 |
177.2 | 98.2 | 150 | 41 | 3.0 | 12.00 | 25 | 4 | |
Cotinine-D3 | 180.2 | 80.0* | 150 | 36 | 3.0 | 14.00 | 31 | 4 |
180.2 | 101.2 | 150 | 36 | 3.0 | 4.00 | 27 | 4 | |
Norcotinine | 163.2 | 80.2* | 150 | 51 | 10.0 | 10.00 | 33 | 6 |
163.2 | 118.1 | 150 | 41 | 10.0 | 10.00 | 29 | 6 | |
Norcotinine-D4 | 167.2 | 84.2* | 150 | 46 | 10.5 | 12.00 | 33 | 6 |
167.2 | 139.2 | 150 | 46 | 10.5 | 12.00 | 27 | 6 | |
Nornicotine | 149.2 | 80.2* | 150 | 36 | 4.5 | 12.00 | 27 | 4 |
149.2 | 130.1 | 150 | 36 | 4.5 | 12.00 | 25 | 4 | |
Nornicotine-D4 | 153.25 | 134.1 | 150 | 36 | 4.5 | 14.43 | 27 | 4 |
153.25 | 84.1* | 150 | 36 | 4.5 | 14.43 | 29 | 4 | |
Period 2 | ||||||||
Nicotine | 163.2 | 84.2* | 250 | 36 | 4.5 | 12.00 | 29 | 8 |
163.2 | 132.0 | 250 | 36 | 5.5 | 12.00 | 21 | 6 | |
Nicotine-D4 | 167.2 | 136.0* | 250 | 36 | 6.0 | 10.00 | 21 | 4 |
167.2 | 121.2 | 250 | 36 | 6.0 | 10.00 | 35 | 6 |
Denotes quantifier transition
Declustering Potential
Collision Entrance Potential
Cell Exit Potential
trans-3’-Hydroxycotinine