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. Author manuscript; available in PMC: 2009 Nov 10.

Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jan 16;863(1):107–114. doi: 10.1016/j.jchromb.2008.01.001

Table 3.

Nicotine and Metabolites in Meconium by LC-APCI-MS/MS: Imprecision and Accuracy

	Intra-day imprecision (% RSD^a, N=5)			Inter-day imprecision (% RSD, N=20)			Accuracy (% of target, N=20)

	Low	Medium	High	Low	Medium	High	Low	Medium	High
OH-cotinine^b	7.8	7.4	5.5	16.6	5.5	5.2	84.7	77.6	77.0
Cotinine	5.8	7.4	5.1	19.9	5.8	5.2	88.0	97.2	94.2
Norcotinine	7.7	3.9	3.9	9.8	5.3	4.5	82.3	77.8	76.6
Nornicotine	16.9	5.5	3.9	19.8	7.8	5.9	90.5	79.0	77.8
Nicotine	10.7	6.7	6.8	10.8	7.4	6.8	105.6	93.4	93.2

^a

Relative standard deviation

^b

trans-3’-Hydroxycotinine