Table 1.
The overexpressed (≥ 1.75) proteins identified in PanIN 3 tissues (The table only includes overexpressed proteins identified and quantified with two or more peptides)
| Protein ID | Description | Gene Symbol |
Group prob. |
Percent coverage |
No. of identified peptides |
Quantitaive Method |
Ratio (PanIN/NL) |
SD | Over expressed in cancer tissues? |
Over expressed in pancreatitis tissues? |
|---|---|---|---|---|---|---|---|---|---|---|
| IPI00412579, IPI00413986 |
25 kDa protein, 60S ribosomal protein L10a |
RPL10A;L OC137107 |
1.00 | 26.40 | 24.00 | ICA/iTRAQ | 5.88 | 1.38 | ||
| IPI00003865 | Isoform 1 of Heat shock cognate 71 kDa protein |
HSPA8 | 1.00 | 5.60 | 8.00 | ICAT | 5.26 | 0.55 | Y (ICAT) | |
| IPI00012119, IPI00219403 |
Isoform A of Decorin precursor, Isofrom D of Decorin precursor |
DCN | 1.00 | 19.20 | 16.00 | ICAT | 4.76 | 0.91 | ||
| IPI00024284, IPI00747758 |
Basement membrane-specific heparan sulfate proteoglycan core protein precursor, 365 kDa protein |
HSPG2 | 1.00 | 0.40 | 2.00 | ICAT/iTRAQ | 3.85 | 0.89 | ||
| IPI00219910 | Flavin reductase | BLVRB | 1.00 | 9.00 | 6.00 | ICAT | 3.23 | 4.27 | ||
| IPI00032179, IPI00165421 |
Antihrombin III variant, SERPINC1 protein |
SERPINC 1 | 1.00 | 5.00 | 5.00 | ICAT | 2.22 | 0.44 | Y (ICAT) | |
| IP100443909 | Isoform 1 of MIR-interacting saposin- like protein precursor |
CNPY2 | 1.00 | 34.10 | 11.00 | ICAT | 2.22 | 0.40 | ||
| IPI00302592, IPI00333541, IPI00644576 |
Filamin-A, Filamin A, alpha, Filamin A, alpha |
FLNA | 1.00 | 3.40 | 28.00 | ICAT | 2.17 | 0.66 | ||
| IPI00013991, IPI00220709, IPI00513698, IPI00646748 |
Isoform 2 of Tropomyosin beta chain, Isoform 1 of Tropomyosin beta chain, Tropomysin 2, Tropomysin 2 |
TPM2 | 1.00 | 4.90 | 4.00 | ICAT | 2.08 | 0.52 | Y (ICAT) | Y (ICAT) |
| IPI00216694 | plastin 3 | PLS3 | 1.00 | 6.50 | 5.00 | ICAT | 1.96 | 0.35 | ||
| IPI00018146 | 14-3-3 protein theta | YWHAQ | 1.00 | 11.80 | 3.00 | ICAT | 1.92 | 0.52 | ||
| IPI00013976 | Laminin beta-1 chain precursor | LAMB1 | 1.00 | 2.40 | 2.00 | ICAT | 1.89 | 0.32 | ||
| IPI00219219 | Galectin-1 | LGALS1 | 1.00 | 20.10 | 14.00 | ICAT | 1.85 | 2.95 | Y (ICAT) | |
| IPI00382804 | EEF1A protein (Fragment) | EEF1A1 | 1.00 | 24.70 | 4.00 | ICAT | 1.79 | 0.45 | ||
| IPI00294140, IPI00412253 |
Isoform 2 of Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor,Isofrom 1 of Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor |
MCCC2 | 1.00 | 3.80 | 5.00 | ICAT | 1.75 | 0.49 | ||
| IPI00008530, IPI00396373, IPI00556485, IPI00737483, IPI00737567, IPI00737840, IPI00739014 |
PREDICTED: similar to acidic ribosomal phosphoprotein P0 isoform 4,PREDICTED: similar to acidic ribosomal phosphoprotein P0 isoform 2,PREDICTED: similar to acidic ribosomal phosphoprotein P0 isoform 3,BLOCK 23,PREDICTED: similar to 60S acidic ribosomal protein P0 (L10E) isoform 5, RPLP0 protein,60S acidic ribosomal protein P0 |
RPLP0 | 0.99 | 10.40 | 2.00 | ICAT | 1.75 | 0.83 | ||
| IPI00382950 | Beta-globin gene from a thalassemia patient, complete cds |
HBB | 1.00 | 56.00 | 47.00 | iTRAQ | 4.00 | 0.02 | Y (ICAT/iTRAQ) | |
| IPI00026272, IPI00031562, IPI00081836, IPI00216456, IPI00216457, IPI00220855, IPI00255316, IPI00291764, IPI00303315, IPI00339274, IPI00552873, IPI00645519 |
Histone H2A type 1-B,Histone H2A type 3,Histone H2A type 1- H,Histone H2A type 1-j,Histone H2A type 1-E,Histone H2A type 1,Histone H2A type 2-C,H2A histone family, member j isoform 2,Histone H2A type 1-C,Histone H2A type 2-A,Histone H2A type 1- D,Histone H2A.c/d/i/n/p |
HIST1H2 AB;HIST1 H2AE |
1.00 | 20.50 | 5.00 | iTRAQ | 2.79 | 0.03 | Y (iCAT) | |
| IPI00473011 | Hemoglobin delta subunit | HBB;HBD | 1.00 | 58.20 | 11.00 | iTRAQ | 2.64 | 0.04 | Y (ICAT/iTRAQ) | |
| IPI00183695 | Calpactin-1 light chain | S100A10 | 0.99 | 17.10 | 4.00 | iTRAQ | 2.27 | 0.01 | Y (ICAT/iTRAQ) | Y (iTRAQ) |
| IPI00556589, IPI00719622 |
40S ribosomal protein S28,PREDICTED: similar to 40S ribosomal protein S28 |
RP528 | 0.96 | 17.40 | 2.00 | iTRAQ | 2.17 | 0.02 | ||
| IPI00008603, IPI00023006, IPI00025416 |
Actin, alpha cardiac,Actin, gamma- enteric smooth muscle,Actin, aortic smooth muscle |
ACTA2;A CTG2 |
1.00 | 51.90 | 21.00 | iTRAQ | 2.14 | 0.02 | Y (ICAT/iTRAQ) | Y (iTRAQ) |
| IPI00550315, IPI00644379 |
Ig kappa chain C region,Ig kappa chain C region |
IGKV3-20 | 0.99 | 22.10 | 2.00 | iTRAQ | 2.09 | 0.02 | Y (iTRAQ) | Y (iTRAQ) |
| IPI00386854, IPI00396378, IPI00414696, IPI00477522 |
Spice Isoform B1 of Heterogeneous nuclear ribonucleoproteins A2\B1,Splice Isoform A2 of Heterogeneous nuclear ribonucleoproteins A2\B1,Heterogeneous nuclear ribonucleoprotein A2\B1 isoform A2; Heterogeneous nuclear ribonucleoprotein A2; Heterogeneous nuclear ribonucleoprotein B1; nuclear ribonucleoprotein particle A2 protein,HNRPA2B1 protein |
HNRNPA2B1 | 1.00 | 22.10 | 6.00 | iTRAQ | 2.05 | 0.04 | ||
| IPI00477457, IPI00478348 |
46 kDa protein, Similar to Heterogeneous nuclear ribonucleoprotein H |
HNRNPF | 1.00 | 14.80 | 3.00 | iTRAQ | 1.92 | 0.02 | Y (iTRAQ) | |
| IPI00298308, IPI00739452 |
Aldehyde dehydrogenase 1 family, member L2, PREDICTED: aldehyde dehydrogenase 1 family, member L2 |
ALDH1L2 | 1.00 | 4.60 | 7.00 | iTRAQ | 1.82 | 0.07 | Y (iTRAQ) | |
| IPI00021792 | Phospholipase A2 precursor | PLA2G1B | 1.00 | 23.00 | 11.00 | iTRAQ | 5.22 | 0.03 | ||
| IPI00298547 | Protein DJ-1 | PARK7 | 1.00 | 7.90 | 2.00 | iTRAQ | 4.89 | 0.00 | Y (iTRAQ) | |
| IPI00514424, IPI00002412, IPI00514248 |
Palmitoyl-protein thioesterase 1, Palmitoyl-protein thioesterase 1 precursor,Palmitoyl-protein thioesterase 1 |
PPT1 | 0.97 | 6.30 | 2.00 | iTRAQ | 4.31 | 0.01 | Y (iTRAQ) | |
| IPI00220834 | ATP-dependent DNA helicase 2 subunit 2 |
XRCC5 | 1.00 | 2.50 | 2.00 | iTRAQ | 4.15 | 0.01 | Y (iTRAQ) | |
| IPI00748319, IPI00642800, IPI00644431, IPI00641952, IPI00552922, IPI00641926, IPI00166874, IPI00641325, IPI00643815, IPI00062206, IPI00641634, IPI00640787, IPI00641829, IPI00328343, IPI00642880 |
HLA-B associated transcript 1 (Fragment),26 kDa protein,ATP- dependent RNA helicase DDX39,HLA-B associated transcript 1 (Fragment),HLA-B associated transcript 1 (Fragment),HLA-B associated transcript 1, DDX39 protein,HLA-B associated transcript 1, HLA-B associated transcript 1, DEAD (Asp-Glu-Ala- Asp) box polypeptide 39, isoform 2,25 kDa protein,HLA-B associated transcript 1,29 kDa protein,Spliceosome RNA helicase BAT1, HLA-B associated transcript 1 |
BAT1 | 0.99 | 5.30 | 5.00 | iTRAQ | 3.48 | 0.01 | Y (iTRAQ) | |
| IPI00007752, IPI00011654, IPI00647896, IPI00645452 |
Tubulin beta-2C chain,Tubulin beta- 2 chain,Tubulin,beta polypeptide,Tubulin,beta polypeptide |
TUBB2C | iTRAQ | 3.03 | 0.01 | Y (iTRAQ) | ||||
| IPI00453473 | Histone H4 | HIST1H4A | 1.00 | 18.60 | 2.00 | iTRAQ | 2.88 | 0.03 | ||
| IPI00018553 | Caldecrin precursor | CTRC | 1.00 | 17.20 | 10.00 | iTRAQ | 2.60 | 0.12 | ||
| IPI00643041 | GTP-binding nuclear protein Ran | RAN | 0.99 | 6.50 | 4.00 | iTRAQ | 2.56 | 0.01 | Y (iTRAQ) | Y (ICAT) |
| IPI00221225, | annexin IV,ANXA4 protein | ANXA4 | 1.00 | 23.40 | 21.00 | iTRAQ | 2.45 | 0.03 | Y (ICAT) | |
| IPI00654755 | Hemoglobin beta subunit | HBB | 1.00 | 74.70 | 157.00 | iTRAQ | 2.30 | 0.01 | ||
| IPI00013860, IPI00479966 |
3-hydroxyisobutyrate dehydrogenase,mitochondrial precursor,Hypothetical protein (Fragment) |
HIBADH | 1.00 | 4.20 | 3.00 | iTRAQ | 2.25 | 0.04 | ||
| IPI00290460 | EUkaryotic translation initiation factor 3 subunit 4 |
EIF3G | 0.99 | 5.00 | 5.00 | iTRAQ | 2.21 | 0.02 | ||
| IPI00025460, IPI00022498, IPI00008752, IPI00008753, IPI00457184, IPI00008750, IPI00647104, IPI00472662, IPI00456560, IPI00413064 |
Metallothionein- 1A,Metallothionein-2,Splice Isoform 1 of Metallothionein- 1G,Metallothionein-1X,PREDICTED: similar to metallothionein 1G,Metallothionein-1H,7kDa protein,Metallothionein- 1I,PREDICTED: hypothetical protein XP_498969,Splice Isoform 2 of Mctallothoncin 1G |
MT1A | 1.00 | 13.10 | 4.00 | iTRAQ | 2.20 | 0.03 | ||
| IPI00298497 | Fibrinogen beta chain precursor | FGB | 0.97 | 2.00 | 8.00 | iTRAQ | 2.17 | 0.01 | Y (iCAT/iTRAQ) | Y (ICAT) |
| IPI00465315 | Cytochrome c | CYCS | 0.99 | 10.60 | 8.00 | iTRAQ | 2.10 | 0.01 | ||
| IPI00456969, IPI00477531 |
Dynein heavy chain, cytosolic 532 kDa protein |
DYNC1H1 | 1.00 | 1.00 | 6.00 | iTRAQ | 1.96 | 0.02 | ||
| IPI00418471 | Vimentin | VIM | 1.00 | 62.40 | 50.00 | iTRAQ | 1.96 | 0.00 | Y IICAT/iTRAQ) | Y (iTRAQ) |
| IPI00717044, IPI00001508 |
INSIGF long transport variant, Insulin precursor |
INS | 0.99 | 6.40 | 16.00 | iTRAQ | 1.94 | 0.01 | ||
| IPI00009771 | Lamin-B2 | LMNB2 | 0.99 | 1.60 | 2.00 | iTRAQ | 1.93 | 0.01 | Y (iTRAQ) | |
| IPI00736803, IPI00745291, IPI00645201, IPI00216587 |
PREDICTED: similar to ribosomal protein SB, Similar to ribosomal protein S8, Ribosomal protein S8, 405 ribosomal protein S8 |
RPS8 | 0.92 | 12.60 | 2.00 | iTRAQ | 1.91 | 0.01 | ||
| IPI00604784, IPI00306140, IPI00744153 |
glucagon preprdprotein, Glucagon precursor,21kDa protein |
GCG | 1.00 | 12.80 | 7.00 | iTRAQ | 1.91 | 0.01 | Y (iTRAQ) | |
| IPI00292709 | Phosphoenopyruvate carboxykinase, cytosolic |
PCK1 | 1.00 | 1.30 | 10.00 | iTRAQ | 1.89 | 0.02 | ||
| IPI00021447 | Alpha-amylase2B precursor | AMY2B | 1.00 | 26.60 | 4.00 | iTRAQ | 1.87 | 0.03 | ||
| IPI00745705, IPI00025476 |
Amylase,alpha 2A;pancreatic variant (Fragment),pancreatic alpha-amylase precursor |
AMY1A;1B;1C;2A | 1.00 | 30.30 | 44.00 | iTRAQ | 1.83 | 0.02 | ||
| IPI00555610 | 313 kDa protein | AHNAK | 1.00 | 10.00 | 19.00 | iTRAQ | 1.83 | 0.01 | Y (iTRAQ) | Y (iTRAQ) |
| IPI00472119, IPI00419880 |
30 kDa protein, 40S ribosomal protein S3a |
RPS3A | 1.00 | 8.00 | 9.00 | iTRAQ | 1.79 | 0.02 | ||
| IPI00329801 | Annexin AS | ANXA5 | 1.00 | 37.00 | 15.00 | iTRAQ | 1.78 | 0.01 | Y (iTRAQ) | |
| IPI00020987 | Prolargin precursor | PRELP | 1.00 | 8.60 | 4.00 | iTRAQ | 1.78 | 0.02 | Y (iTRAQ) | |
| IPI00215790 | 60S ribosomal protein L38 | RPL38 | 0.98 | 18.80 | 2.00 | iTRAQ | 1.78 | 0.03 | ||
| IPI00216085 | Cytochrome c oxidase sububit VIb isoform 1 |
COX6B1 | 0.99 | 12.90 | 6.00 | iTRAQ | 1.77 | 0.02 | ||
| IPI00744444, IPI00335168, IPI00413922 |
17 kDa protein,myosin, light polypeptide 6,alkali,smooth muscle and non-muscle isoform 1,Splice isoform Smooth muscle of Myosin light polypeptide 6 |
MYL6;MYL6B | 1.00 | 10.00 | 3.00 | iTRAQ | 1.75 | 0.00 | Y (iTRAQ) | |
| IPI00013808 | Alpha-actinin-4 | ACTN4 | 1.00 | 26.60 | 18.00 | iTRAQ | 1.75 | 0.01 | Y (iTRAQ) |