. Author manuscript; available in PMC: 2009 Nov 10.

Published in final edited form as: Biochemistry. 2009 Jun 30;48(25):5963–5971. doi: 10.1021/bi900140c

Table 3.

P–O distances to the nucleophile and leaving group in the transition state for the hydrolysis of the dGTP analogues in solution.

X	pK_a	P-O_nuc	P-O_lg
O	8.9	2.0	1.8
CHF	9.0	2.0	1.8
CHCl	9.5	2.0	1.8
CHBr	9.9	2.0	1.95
CH₂	10.5	2.0	1.65
CF₂	7.8	2.0	1.8
CFCl	8.4	2.0	1.95
CCl₂	8.9	2.0	1.8
CBr₂	9.3	2.0	1.8