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. 2009 Nov 20;4(11):e7923. doi: 10.1371/journal.pone.0007923

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Yu, Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: The frequency spectrum and distortion products of OHC response to a two-sinusoidal electrical stimulation (f₁ = 976.56 Hz, f₂ = 1171.87 Hz, and V_p−p = 25 mV) in patch-clamp recording. Inset: A waveform of OHC response. B: The amplitudes of OHC frequency responses at different DC holding potentials. The amplitudes are normalized to those at DC holding potential of −120 mV. C: OHC distortion products at different holding potentials of the DCs. Depolarization of the DCs decreased OHC distortion products. Asterisks indicate p<0.05 (t test). D: Membrane potentials of DCs alter the OHC distortion product. The sum frequency distortion (f₁+f₂) was displayed. Perfusion of 1 mM LuCl₃ reduced the effect.