Figure 2. Productive signaling is determined by both 
and 
in a model of kinetic proofreading with signal persistence.
Results are shown for kinetic proofreading (A–C) without signal persistence and (D–F) with signal persistence (see Figure 1). In all panels we show the probability of a productive signal (
) after 30 s and the threshold is set such that productive signaling requires 15 s of binding (
, 
). Shown in panels (A,D) is 
for indicated on-rates while panels (B,E) show contours of 
as a function of both 
and 
for a single pMHC. In panels (C,F) we show results for 10 pMHC by plotting the probability that at least 1 of 10 pMHC transduces a productive signal 
. Parameters: 
s, 
, 
(TCR concentration), and 
.