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. 2009 Nov 26;5(11):e1000578. doi: 10.1371/journal.pcbi.1000578

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Dushek et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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We perform spatial Monte Carlo simulation of pMHC diffusing and reacting to TCR on a lattice. The simulation begins with the pMHC bound at the center of a TCR cluster () containing the indicated number of TCR and a homogeneous distribution of TCR () is assumed outside. Each TCR in the simulation is independent and performs stochastic kinetic proofreading with signal persistence. The simulation is terminated when or a productive signal is transduced. (A) Fraction of simulations that are terminated by a TCR achieving productive signaling as a function of () for several values of the number of TCR per cluster. (B) The number of unique TCR bound before the simulation terminates. A peak arises because rebinding to the same TCR is probable at large on-rates while at small on-rates serial binding of TCR is small. (C) Fraction of simulations that terminate with the pMHC outside of the TCR cluster. Each data point represents the mean of 500 simulations. Figure S1 shows results in the presence of coreceptors. Parameters: , , , , .

Inline graphic — We perform spatial Monte Carlo simulation of pMHC diffusing and reacting to TCR on a lattice. The simulation begins with the pMHC bound at the center of a TCR cluster () containing the indicated number of TCR and a homogeneous distribution of TCR () is assumed outside. Each TCR in the simulation is independent and performs stochastic kinetic proofreading with signal persistence. The simulation is terminated when or a productive signal is transduced. (A) Fraction of simulations that are terminated by a TCR achieving productive signaling as a function of () for several values of the number of TCR per cluster. (B) The number of unique TCR bound before the simulation terminates. A peak arises because rebinding to the same TCR is probable at large on-rates while at small on-rates serial binding of TCR is small. (C) Fraction of simulations that terminate with the pMHC outside of the TCR cluster. Each data point represents the mean of 500 simulations. Figure S1 shows results in the presence of coreceptors. Parameters: , , , , .