Table II.
Changes in expression levels of ISG differently regulated after infection with the Eystrup strain of CSFV. The ISG listed were found differently regulated between the two CSFV strains. Eystrup (E) and Paderborn (P) gene expression values correspond to the mean Log2 ratio related to the non-infected reference. Bold data are two-class SAM significant.
| Gene name | GenBank accession number | Log2 ratio |
|||||
|---|---|---|---|---|---|---|---|
| D1 |
D2 |
D3 |
|||||
| E | P | E | P | E | P | ||
| Cell death/apotosis | |||||||
| IFIH1 | NM_001100194 | 1.630 | 0.126 | 2.304 | 1.658 | 1.993 | 1.545 |
| XAF1 | AK232641 | 1.058 | 0.244 | 2.183 | 1.315 | 1.696 | 1.485 |
| OAS1 | NM_214303 | 1.080 | 0.238 | 2.106 | 1.471 | 1.824 | 1.608 |
| IFI44 | AK233687 | 1.243 | 0.197 | 1.443 | 1.126 | 0.964 | 0.446 |
| NMI | AK234080 | 0.900 | −0.115 | 1.378 | 0.746 | 1.065 | 0.661 |
| CASP4 | AK231138 | 0.726 | −0.028 | 1.166 | 0.684 | 1.060 | 0.522 |
| CASP1 | NM_214162 | 0.948 | 0.206 | 0.804 | 0.915 | 1.020 | 0.678 |
| USP18 | NM_213826 | 0.851 | 0.021 | 0.649 | 0.712 | 0.781 | 0.535 |
| IFI16 | XM_001929212 | 0.530 | −0.052 | 0.632 | 0.451 | 0.481 | 0.228 |
| IRF7 | NM_001097428 | 0.477 | 0.081 | 0.478 | 0.503 | 0.572 | 0.305 |
| POMP | AK240274 | 0.178 | −0.301 | 0.393 | 0.188 | 0.343 | 0.170 |
| CD47 | NM_001025079 | 0.730 | −0.041 | 0.239 | 0.443 | 0.601 | 0.345 |
| ETS1 | NM_005238 | −0.181 | 0.344 | −0.306 | −0.063 | −0.079 | −0.254 |
| Antiviral response | |||||||
| ISG20 | NM_001005351 | 1.322 | 0.192 | 2.869 | 1.488 | 2.049 | 1.662 |
| GBP2 | NM_001128474 | 1.403 | 0.089 | 1.180 | 1.045 | 1.005 | 0.744 |
| GBP1 | NM_001128473 | 1.358 | 0.405 | 0.581 | 0.462 | 0.906 | 0.577 |
| CCL5 | NM_001129946 | −1.265 | −0.289 | −1.169 | −0.916 | −0.525 | −0.688 |
| Mobility/adhesion | |||||||
| SELL | NM_001112678 | 0.336 | 0.191 | 0.168 | 0.186 | 0.471 | 0.038 |
| CD9 | NM_214006 | −0.162 | 0.145 | −0.398 | 0.110 | −0.261 | −0.296 |
| VIM | AY368193 | −0.361 | 0.309 | −0.690 | −0.098 | −0.869 | −0.414 |
| Signaling | |||||||
| STAT2 | NM_213889 | 1.050 | 0.200 | 0.905 | 0.783 | 0.910 | 0.584 |
| JAK2 | NM_214113 | 0.553 | −0.018 | 0.039 | 0.092 | 0.481 | 0.161 |
| NCF2 | NM_001123142 | 0.359 | −0.107 | 0.211 | 0.291 | 0.495 | 0.128 |
| Antigen presentation | |||||||
| TAP2 | DQ227991 | 0.470 | 0.008 | 0.496 | 0.321 | 0.443 | 0.246 |
| SLA-DMb | NM_001113707 | 0.195 | 0.183 | −0.391 | 0.170 | −0.257 | −0.075 |
| SLA-DRa | NM_001113706 | −0.095 | 0.137 | −0.345 | 0.085 | −0.486 | −0.211 |
| Protein translation | |||||||
| WARS | EU715029 | 0.276 | 0.014 | 0.221 | 0.199 | 0.035 | 0.104 |
| EIF2S2 | XM_001929150 | 0.148 | −0.255 | 0.035 | −0.001 | 0.064 | −0.078 |
| Inflammatory response | |||||||
| AIF1 | XM_001928769 | 0.425 | −0.084 | 0.064 | 0.351 | 0.188 | 0.151 |
| Lymphocyte activation | |||||||
| CD69 | AF484233 | 0.710 | 0.279 | −0.030 | 0.012 | 0.605 | −0.423 |
| Unknown | |||||||
| IFIT3 | XM_001928703 | 1.663 | 0.370 | 2.723 | 2.045 | 2.459 | 1.779 |