Table 1.
Genes differentially induced in response to capreomycin and PA-824 relative to other drugs.
| ORF | Gene | Product/Function | Score | q-value % |
|---|---|---|---|---|
| Rv2657c | — | Probable phirv2 prophage protein | 4.73 | 0 |
| Rv2374c | hrcA | Probable heat shock protein transcriptional repressor | 4.12 | 0 |
| Rv0354c | PPE7 | PPE family protein | 3.80 | 0 |
| Rv1364c | — | Conserved hypothetical protein | 3.54 | 0 |
| Rv2304c | — | Hypothetical protein | 3.52 | 0 |
| Rv0367c | — | Hypothetical protein | 3.30 | 0 |
| Rv0607 | — | Hypothetical protein | 3.26 | 0 |
| Rv2466c | — | Conserved hypothetical protein | 3.21 | 0 |
| Rv0830 | — | Conserved hypothetical protein | 3.18 | 0 |
| Rv2557 | — | Conserved hypothetical protein | 3.16 | 0 |
| Rv2142c | — | Hypothetical protein | 3.02 | 0 |
| Rv0654 | — | Probable dioxygenase | 2.99 | 0 |
| Rv1977 | — | Conserved hypothetical protein | 2.99 | 0 |
| Rv2688c | — | Probable antibiotic-transport ATP-binding protein | 2.98 | 0 |
| Rv1285 | cysD | Probable sulfate adenylyltransferase subunit 2 | 2.82 | 1.04 |
| Rv0047c | — | Conserved hypothetical protein | 2.77 | 1.73 |
| Rv2878c | mpt53 | Soluble secreted antigen mpt53 precursor | 2.74 | 1.73 |
| Rv2254c | — | Probable integral membrane protein | 2.63 | 1.86 |
| Rv1986 | — | Probable conserved integral membrane protein | 2.60 | 1.86 |
| Rv2777c | — | Conserved hypothetical protein | 2.60 | 1.86 |
| Rv2413c | — | Conserved hypothetical protein | 2.59 | 1.86 |
| Rv1929c | — | Conserved hypothetical protein | 2.59 | 1.86 |
| Rv3288c | usfY | Putative protein | 2.57 | 1.86 |
| Rv2535c | PEPQ | Probable cytoplasmic peptidase | 2.54 | 2.27 |
| Rv2634c | PE_PGRS46 | PE_PGRS family protein | 2.54 | 2.27 |
| Rv1646 | PE17 | PE family protein | 2.49 | 2.72 |
| Rv2749 | — | Conserved hypothetical protein | 2.46 | 2.72 |
| Rv3452 | cut4 | Probable cutinase precursor cut4 | 2.44 | 3.22 |
| Rv0192 | — | Conserved hypothetical protein | 2.41 | 3.22 |
| Rv1687c | — | Probable conserved ATP-binding protein ABC transporter | 2.41 | 3.22 |
| Rv1087 | PE_PGRS21 | PE_PGRS family protein | 2.37 | 4.35 |
| Rv1566c | — | Possible inv protein | 2.36 | 4.35 |
| Rv2504c | scoA | Probable succinyl-coa3-ketoacid-coenzyme A transferase | 2.35 | 4.35 |
| Rv0834c | PE_PGRS14 | PE_PGRS family protein | 2.33 | 4.35 |
| Rv0274 | — | Conserved hypothetical protein | 2.33 | 4.35 |
| Rv2162c | PE_PGRS38 | PE_PGRS family protein | 2.30 | 4.35 |
| Rv0365c | — | Conserved hypothetical protein | 2.30 | 4.35 |
| Rv3550 | echA20 | Probable enoyl-CoA hydratase | 2.27 | 4.67 |
| Rv3367 | PE_PGRS51 | PE_PGRS family protein | 2.26 | 4.67 |
| Rv2802c | — | Hypothetical arginine and alanine rich protein | 2.25 | 4.67 |
| Rv2291 | sseB | Probable thiosulfate sulfurtransferase | 2.25 | 4.67 |
| Rv3189 | — | Conserved hypothetical protein | 2.25 | 4.67 |
*Score: the t-statistic score. q-value: the level of significance based on SAM.