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Inhibition Constants and Selectivity Ratios of PUGNAc and 2-N-acyl Derivatives for Glycoside Hydrolase Families GH3, GH84, and GH20
| Compound | Family 3 VcNagZ KI (μM)a | Family 84 O-GlcNAcase KI (μM)a | Family 20 ß-hexosaminidase KI(μM)a | Selectivity ratio KI (O-GlcNAcase)/KI (VcNagZ) | Selectivity ratio KI (ß-hexosaminidase)/KI (VcNagZ) |
|---|---|---|---|---|---|
| PUGNAc | 0.048 | 0.046 | 0.036 | 1 | 0.75 |
| N-butyryl-PUGNAc | 0.26 | 2.5 | 26 | 9.6 | 100 |
| N-valeryl-PUGNAc | 0.33 | 40 | 220 | 121 | 667 |
