Figure 2.

The RPL21 and RPS9 gene cluster is fungal-specific. The synteny is conserved in euascomycetes (i.e., Neurospora crassa, Paracoccidioides brasiliensis, Botrytis cinerea, Chaetomium globosum) and hemi-ascomycete (i.e., Saccharomyces cerevisiae), homobasidiomycete (i.e., Laccaria bicolor) and heterobasidiomycetes (i.e., Puccinia graminis f. sp. tritici and Cryptococcus neoformans) as well as in Mucor circinelloides and the three microsporidia. However, the genes are not syntenic and are completely unlinked in three protozoan, Entamoeba histolytica, Entamoeba dispar and Giardia lamblia genomes. The genome of Schizosaccharomyces pombe encodes RPS9 unlinked to RPL21, and instead RPS4 forms a gene cluster with RPL21. Gene sizes are not to scale.