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The α6-selective antagonist MII[H9A;L15A] dose-dependently blocks expression of nicotine reward. Doses of 6 and 4.5 pmol of MII[H9A;L15A], but not 1.5 pmol of MII[H9A;L15A], block the expression of nicotine CPP in mice. The 6-pmol dose of MII[H9A;L15A] had no effect in saline-treated mice. Each point represents the mean ± S.E.M. of eight to 10 mice per group. *, p < 0.05 versus saline groups. veh, vehicle.
