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. 2009 Nov;331(2):591–597. doi: 10.1124/jpet.109.158162

Fig. 2.

Fig. 2.

MAGL inhibitor JZL184 selectively amplifies the effect of 2-AG, whereas FAAH inhibitor URB597 amplifies the effect of AEA. A, bath application of 2-AG (10 μM) depressed EPSCs in mouse cerebellar Purkinje neurons (n = 5). This depression was enhanced by JZL184 (JZL, 100 nM, n = 5), but not by URB597 (1 μM, n = 3). The 2-AG-induced depression of EPSCs was blocked by AM251 (2 μM). B, bath application of AEA (25 μM) depressed EPSCs in mouse cerebellar Purkinje neurons (n = 4). This depression was enhanced by URB597 (1 μM, n = 3), but not by JZL184 (JZL, 100 nM, n = 4). The AEA-induced depression of EPSCs was blocked by AM251 (2 μM).