Pharmacological blockade and genetic knockout of FAAH did not affect DSE and DSI. A, URB597 (1 μM) did not affect DSE in cerebellar Purkinje neurons (n = 5 each group). B, URB597 (1 μM) did not affect DSI in CA1 pyramidal neurons (n = 9–10). C and D, cerebellar DSE (C) and hippocampal DSI (D) were not significantly different in slices prepared from FAAH−/− and FAAH+/+ mice (n = 7–9). E, JZL184 (JZL, 100 nM) prolonged DSE to a similar extent in cerebellar slices from FAAH−/− and FAAH+/+ mice (n = 7 each group). F, URB597 did not affect DSE in slices from FAAH−/− and FAAH+/+ mice (n = 7 each group).